Nitrate in drinking water and risk of colorectal cancer in Yogyakarta, Indonesia

Fathmawati, Fathmawati and Fachiroh, Jajah and Gravitiani, Evi and Sarto, Sarto and Husodo, Adi Heru (2017) Nitrate in drinking water and risk of colorectal cancer in Yogyakarta, Indonesia. Journal of Toxicology and Environmental Health, Part A, 80 (2). pp. 120-128. ISSN 1528-7394

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Abstract

Nitrate concentration in well water in Yogyakarta, Indonesia, and its surroundings tended to increase rapidly from time to time, and it may be associated with an elevated risk for several types of cancer. The purpose of this study was to examine the association between nitrate in drinking water and colorectal cancer (CRC) risk occurrence. A case-control study was conducted in Yogyakarta Special Province. Pathologically confirmed 75 CRC patients and 75 controls were consulted and their individual well water was sampled and examined for nitrate concentrations. Logistic regression analysis was conducted to establish the association between nitrate and CRC risk development. There was a significant correlation between nitrate in drinking water and CRC occurrence, and this value was relatively stable after being adjusted for protein intake, smoking history, age, and family history of cancer. These findings demonstrated that the risk of CRC development was fourfold among those with >10 years of nitrate exposure from well water compared with those with ≤10 years of nitrate exposure. Consequently, a significant association between nitrate in drinking water and occurrence of CRC in Yogyakarta was established.

Item Type:	Article
Subjects:	R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Depositing User:	Dr. Fathmawati M.Kes.
Date Deposited:	01 Jun 2023 01:22
Last Modified:	02 Jun 2023 06:26
URI:	http://repo.poltekkes-pontianak.ac.id/id/eprint/357

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