Potential Role of Mitragynine as Lipolysis Stimulator via Adrenergic Signalling: Docking Model Study

Abidin, Khoirul Rista and Lesmana, Ronny and Syamsunarno, Mas Rizky Anggun Adipurna and Dharma, Kelana Kusuma (2022) Potential Role of Mitragynine as Lipolysis Stimulator via Adrenergic Signalling: Docking Model Study. Pharmacognosy Journal, 14 (5). pp. 527-531. ISSN 09753575

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Abstract

Backgrounds: Mitragynine is the most popular of the more than 50 alkaloids contained in M.Speciosa. In particular, the Mitragynine alkaloid has the potential to increase lipid (fats) metabolism through specific pathways such as adenylyl cyclase signaling via adrenergic receptors. In this case, Asp Amino acid and Ser are the types of residues that can activate adenylyl cyclase to initiate a series of activities in cells. Methods: This study used Mitragynine ligand and adrenergic receptors (α1b, α2a, α2b, α2c dan β1). The receptor candidates were tested using Autodock whose test results were presented in the form of tables and 3-dimensional images using the Biovia Discovery Studio. Results: Hydrogen bonds were formed between Mitragynine and the amino acids Asp and Ser at the β1-adrenergic receptor. The binding amino acids were found in Ser20 and Asp21 with energy bond of -5.26 kcal/mol and IC50: 111.35 ppm. Meanwhile, at the adrenergic receptor α2b there was only Asp residue that formed hydrogen bond with Mitragynine namely Asp218A. The energy bond formed between the two was -5.19 kcal/mol and IC50: 125.04 ppm. Conclusion: Mitragynine has the potential to stimulate lipolysis through the pathways of α2b and β1-adrenergic receptors.

Item Type:	Article
Additional Information:	Dr. Kelana Kusuma Dharma, M.Kes., S.Kp is currently working as a Lecturer in Nursing Study Program, Poltekkes Kemenkes Pontianak. He had continued his Doctor in Nursing Program, Universitas Indonesia. His research interest is cardiovascular diseases. Department of Nursing, Politeknik Kesehatan Kementerian Kesehatan Pontianak-78124, Kalimantan Barat, INDONESIA.
Uncontrolled Keywords:	Adrenergic, Docking, Lipolysis, Mitragynine
Subjects:	R Medicine > RT Nursing
Depositing User:	Dr Kelana Kusuma Dharma
Date Deposited:	26 May 2023 10:47
Last Modified:	26 May 2023 23:49
URI:	http://repo.poltekkes-pontianak.ac.id/id/eprint/339

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